It was found that the number of vWF microvessels in the boundary area of ischemic brains was reduced in diabetic mice compared with control (−46.5%, p < 0.01), which was significantly increased in 4-week AKG treated diabetic mice (+42.9%, p < 0.01 vs. Diabetes) (Figure 2G). The gene discussed is VWF; the disease is diabetes mellitus.