In the present study, we investigated the effect of SFN on the regulation of sepsis-induced acute liver injury, explored the effect of SFN on LPS-induced pyroptotic cell death, and provided evidence to mechanistically link Nrf2-HO-1 signaling with the regulation of SFN in hepatocyte pyroptosis and septic acute liver injury. The gene discussed is NFE2L2; the disease is Sepsis.