These findings are consistent with previously reported data on UCS, indicating that, on a molecular level, UCS possesses characteristics of both sarcoma and adenocarcinoma.10 We constructed an oncoprint focusing on pivotal genes involved in UCS-related carcinogenesis to examine the genetic landscape of UCS, including DNA damage response, cell cycle regulation, PI3K/AKT/mTOR signaling pathway, DNA repair mechanisms, and the RAS/MAPK signaling axis (Figure 2). This evidence concerns the gene PIK3CA and sarcoma.