Indeed, Bmal1 deficiency in preclinical models impairs circadian behavior and accelerates aging, leading to muscle atrophy, reduced strength, disrupted sarcomere organization, and decreased mitochondrial content, all key features of sarcopenia (Kondratov et al., 2006; Christian and Benian, 2020; Gao et al., 2020). Here, BMAL1 is linked to sarcopenia.