AKT1 and endothelial dysfunction: BMAL1 disfunction: impaired angiogenesis, vascular remodeling, endothelial dysfunction, heightened thrombosis risk, and reduced eNOS–Akt signalingBmal polymorphisms are associated with hypertensionBMAL1 and REV-ERBα lost of rhythm: impaired mitochondrial biogenesis and reduced cardiac functional reserve, increased risk of heart failureClock gene disfunction impact on acute myocardial infarction incidence and extension