BMAL1 disfunction: impaired angiogenesis, vascular remodeling, endothelial dysfunction, heightened thrombosis risk, and reduced eNOS–Akt signalingBmal polymorphisms are associated with hypertensionBMAL1 and REV-ERBα lost of rhythm: impaired mitochondrial biogenesis and reduced cardiac functional reserve, increased risk of heart failureClock gene disfunction impact on acute myocardial infarction incidence and extension. This evidence concerns the gene AKT1 and myocardial infarction.