Type 2 diabetes/metabolic syndromeCardiovascular DysfunctionDisrupted DNA repairDesynchronized cell-cycle clock genesDisrupted NAD+ biosynthesisCognitive declineImmune dysregulationCancer riskPremature cellular and organismal aging (+1.3 years biological age acceleration)Sleep disturbancesReproductive aging. This evidence concerns the gene CLOCK and type 2 diabetes mellitus.