Researchers have studied the pathogenic mechanism of SARS-CoV-2, the pathogen that causes COVID-19, and have found that the virus mainly exerts its toxic effect by binding to the host receptor membrane ACE2 through its spike S-glycoprotein (Gheblawi et al., 2020), while ACE2 is expressed in a variety of cells in the respiratory tract, so that the SARS-CoV-2 directly infects the bronchial and alveolar epithelial cells, causing lung tissue damage and affecting the ventilation and air exchange function of the body (Sungnak et al., 2020). This evidence concerns the gene ART4 and COVID-19.