Moreover, findings of this study necessitate comprehensive analysis utilizing animal models and clinical samples to elucidate the molecular mechanisms of GC pathogenesis; clarify the roles of CDK1, CDK1, MAPK1, NOXO1, CUL1 and CCNB1 in GC; and identify innovative and promising targets for the early diagnosis and treatment of GC. The gene discussed is CUL1; the disease is gastric cancer.