IFNG and Cowden disease: Since immunization with both RNA formulations resulted in similar production of IFN-γ and similar protection regarding parasitemia, but a lower parasite DNA and inflammatory infiltrate in the heart tissue of animals immunized with RNA encoding full-length TS compared to immunization with RNA encoding TS without SAPA, it can be assumed that the presence of SAPA repeats in the RNA formulation may be beneficial when we design an RNA vaccine for CD.