found that the AUC, sensitivity and specificity of GP73 for the diagnosis of liver fibrosis F≥2, F≥3 and F=4 were 0.828 (64.92%, 90.68%), 0.895 (80.66%, 86.49%), 0.933 (82.61%, 91.24%), respectively, proving that GP73 can also distinguish between significant liver fibrosis and advanced liver fibrosis in patients with liver fibrosis not caused by hepatitis B virus infection (Lu et al., 2017). This evidence concerns the gene GOLM1 and Hepatic fibrosis.