IGHE and atopic eczema: This disease is characterized predominantly by elevated IgE, eosinophilia, severe eczematous dermatitis as early as the first month of life, recurrent skin abscesses without the typical inflammatory signs (warmth, erythema, or tenderness; “cold abscesses”), recurrent cyst-forming pneumonias, and chronic mucocutaneous candidiasis (CMC) (25, 26).