PGM3 and Herpesviridae infectious disease: Autosomal recessive hypomorphic mutations in the phosphoglucomutase 3 gene PGM3 can lead to a clinical SCID phenotype with features of HIES, with elevated IgE, severe atopy, systemic bacterial infections, disseminated Herpesvirus infections, neurologic impairment, and increased autoimmunity (25).