Another potential evidence of potential plasticity between Tfh lineage subsets is that under autoimmune uveitis(AE), the expression of decreasing or deficient STING (Stimulator of interferon genes) could drive Tfh17 polarization, and in the infiltrated tissue, the proportion of Th1 is decreased; however, in the DLN of AE, the Th1 is high (119). This evidence concerns the gene NELFCD and acrodermatitis enteropathica.