PLA2G1B and chronic obstructive pulmonary disease: Given that cell death, inflammatory responses, and oxidative stress represent key pathophysiological mechanisms involved in the progression of COPD, and considering that the aforementioned analysis suggested a potential role of PLA2G1B in influencing these phenotypes, this study employed siRNA transfection to knock down PLA2G1B expression in epithelial cells in order to investigate its association with cell death, inflammatory responses, and oxidative stress (Figure 9E).