Figure 3D illustrates the transcriptomic features of B cells across samples, which were classified into three identifiable B cell subtypes and one unannotated subtype: plasma cells with high CD38 expression, mature B cells with high CD19/CD22 expression, and memory B cells with high CD27 expression (Figure 3E). Further analysis demonstrated that these five B cell subtypes exhibited significant differences in gene expression between normal and tumor tissues (Figure 3F), and the UMAP plots visually depicted the expression of marker genes across the subtypes (Figure 3G). The gene discussed is CD22; the disease is neoplasm.