Of which, core targets (EGFR, STAT3, JAK1) all are enriched in cancer signaling pathways, given their high connectivity in the PPI network (Figure 3C) and established crosstalk in liver fibrosis, we hypothesized that PZH modulates the EGFR/JAK1/STAT3 signaling axis. The gene discussed is STAT3; the disease is Hepatic fibrosis.