ESR1 and Hepatic fibrosis: The processed PPI network was visualized using Cytoscape 3.7.1 software (Figures 3B, C), with strict adherence to the selection criteria, thereby resulting in a total of 20 core targets, including AKT1, IL6, TNF, TP53, VEGFA, JUN, IL1B, EGFR, CASP3, PTGS2, MYC, ESR1, STAT3, HIF1A, MMP9, EGF, PPARG, FOS, CXCL8, and CCND1, which are considered key targets of contributing to the anti-hepatic fibrosis activity of PZH.