In Alzheimer’s disease, GBP2 expression in astrocytes is associated with amyloid plaques; it is markedly increased in astrocytes treated with fibrillar amyloid β-protein 42, and immunolabeling in TgF344-AD rat brains shows enhanced GBP2 expression surrounding amyloid plaques compared to wild-type controls (126). The gene discussed is GBP2; the disease is early-onset autosomal dominant Alzheimer disease.