The clinical spectrum of APS can range from individuals with circulating aPL but no thromboembolic/obstetric disease (NoAPS), to those with moderate-to-large vessel thrombosis (TAPS), pregnancy morbidity (OAPS), and/or microvascular disease (MAPS) (e.g., skin necrosis, aPL-nephropathy or diffuse alveolar hemorrhage) (1, 3). Here, FASLG is linked to autoimmune polyendocrinopathy.