IFNA1 and systemic lupus erythematosus: This activation is a hallmark of several autoinflammatory and autoimmune conditions, including systemic lupus erythematosus (SLE), Aicardi-Goutières syndrome, and STING-associated vasculopathy with onset in infancy (SAVI), where disrupted IFN signaling drives pathological immune activation and tissue damage (3, 11, 12).