ORR 100%, PFS 19.5 months. 18/21 complete remissions, 11 relapses (3–21 months post treatment)Maximal CRS – grade 2, limited ICANSPersistence until day 125 shown for 3 patients19-30% CAR integration, 80-90% PD-1 locus edited. Off target locus identified, no functional consequences. The gene discussed is PDCD1; the disease is congenital rubella syndrome.