Other examples include T cells engineered to express the chemokine receptor CXCR5 to improve migration in CXCL13 rich lung as well as head and neck cancer microenvironments, and CXCR6 expression that improved migration and function in hypoxic CXCL16-rich pancreatic tumor milieus (184, 185). Here, CXCL16 is linked to pancreatic neoplasm.