Initial candidates for overexpression have been the chemokine receptors CCR2 and CXCR2 (receptors for CCL2 and CXCL8/IL-8, respectively) for CAR and transgenic TCR T cells, as well as TILs, which revealed increased tumor infiltration in several models (175–181). The gene discussed is CXCL8; the disease is neoplasm.