As shown in Figure 1, high expression of CD16 and CD64 was significantly associated with better prognosis in HNSCC patients (P < 0.05; Figures 1A1, A2, C1, C2), whereas high expression of CD163 correlated with poorer prognosis (P < 0.05; Figures 1B1, B2, E). The gene discussed is CD163; the disease is head and neck squamous cell carcinoma.