TGFB1 and neoplasm: Integrative multi-omic mapping across 160 tumor sites further demonstrates that mutational processes and anatomic location co-determine immune states, with fold-back inversion–bearing tumors exhibiting elevated TGF-β signaling, T-cell exclusion, and naïve/memory-skewed T-cell compartments—an axis that plausibly marks a TGF-β–high risk group (66–68).