As outlined by spatial and single-cell evidence, risk assignment can integrate a stromal/CAF activity index (e.g., INHBA, periostin, fibronectin), an antigen-presentation index, and quantitative interaction metrics (nearest-neighbor distances and interface lengths among CD8+ T cells, PD-L1+ tumor/myeloid populations, and CAF corridors). The gene discussed is CD8A; the disease is neoplasm.