Treatment with A20 mRNA-LNP resulted in a reduction in the activity of Th2 (Vehicle: 3.49%, A20 mRNA: 2.94%) and Th17 cells (Vehicle: 3.81%, A20 mRNA: 2.73%), which are known to promote fibrotic responses in SSc (Figure 2B). The gene discussed is TNFAIP3; the disease is systemic sclerosis.