Studies have shown that metformin (which inhibits NF-κB nuclear translocation), rapamycin (an mTOR inhibitor), and resveratrol (an activator of the nuclear factor erythroid 2-related factor 2 [Nrf2] pathway) can suppress SASP expression, exerting anti-aging and anti-tumor effects (215–218). This evidence concerns the gene NFE2L2 and neoplasm.