CD4 and neoplasm: In tumor tissues, immune subsets were significantly enriched compared with adjacent tissues, including CD8+ T cells with exhaustion (CD39, TIM3, PD-1) or activation/tissue residency (CD137, CD103) features; CD4+ T cells with activation (CD134, CD137) or regulatory (FOXP3) phenotypes; and dendritic cells expressing TIM3 or CD103.