Collectively, our findings reveal that psoriasis drives distinct alterations in the γδTCR repertoires of peripheral blood and skin, characterized by nominal TRGV9 enrichment and TRDV3 depletion in the skin, along with contrasting disease and age-related patterns in TRGV2-TRGJP1 and TRGV8-TRGJ2 transcript abundance between these compartments compared to healthy controls. This evidence concerns the gene TRGV8 and psoriasis.