To evaluate the therapeutic effect of SR2211, an inverse agonist of RORγ (25), on sweat secretion in a mouse model of hyperhidrosis, mice were intraperitoneally administered with SR2211 (20 mg/kg) or vehicle daily for one week prior to pilocarpine-induced hyperhidrosis (Figure 4A). Here, RORC is linked to Hyperhidrosis.