RHO and cancer: IPA of the top 5 canonical signaling pathways induced uniquely by ERB or human macrophages also revealed that, unlike the signaling pathway profiles in ERBs described for MARV and SUDV, human moMΦs significantly upregulated distinct signaling pathways such as Neutrophil degranulation, RHO GTPase cycle, Interferon alpha/beta signaling, Interferon gamma signaling and Molecular Mechanisms of Cancer (Figure 8E).