CD274 and non-small cell lung carcinoma: Second, in NSCLC, acetate-derived acetyl-CoA acetylates c-Myc to stabilize it and upregulate PD-L1; patient-derived NSCLC organoids show 2.3-fold higher PD-L1 at acetate ≥5 mM, while dietary supplementation exacerbates this effect (229).