Translating these insights requires compartmentalized strategies: tumor-localized LPS sequestration (246) avoids systemic cytokine storm while preserving its immunostimulatory effects (e.g., CD8+ T cell enhancement in osteosarcoma; 206), and aligning LPS interventions with radiotherapy leverages post-irradiation immune priming (221). The gene discussed is CD8A; the disease is neoplasm.