FLT3 and acute myeloid leukemia: Quizartinib • FLT3 (FMS-like tyrosine kinase 3) is the primary target of Quizartinib. Its mechanism is as follows: It binds to the inactive conformation of FLT3. It inhibits autophosphorylation and downstream signaling. It blocks pathways, and causes FLT3-ITD-positive AML cells to undergo apoptosis108