Moreover, the impaired recognition of facial emotions (>50% of our patients) could be linked to the prefrontal mesial cortex.40 This alteration, which is part of the Mini-SEA test, has been previously reported by Scheuer et al. 11 and Chamard et al. 10 in a small cohort of SPG4 patients, as described in frontotemporal dementia (FTD).37 Nevertheless, the fusiform gyrus has been described as having a role in prosopagnosia41 and could be linked to the process of FER. This evidence concerns the gene SPAST and frontotemporal dementia.