APOE and early-onset autosomal dominant Alzheimer disease: These were observed in the medial and lateral temporal lobes among the APOE ε4 non-carriers and Aβ-negative participants, extending to the lateral and medial parietal and lateral occipital regions during symptomatic Alzheimer's disease stages for APOE ε4 carriers and Aβ-positive participants from both ADNI and HABS.