MAPT and Cognitive impairment: Similarly, the presence of Aβ is found to be permissive for tau-related hippocampal dysfunction and memory performance based on the results of a recent investigation.26 Furthermore, despite the similar level of tau pathology, non-demented individuals with pathological levels of Aβ showed higher cognitive impairment, which raises the possibility that the presence of Aβ may increase the toxicity of tau aggregates and downstream neurodegeneration.