Both Aβ and pathological tau burdens have been shown to affect brain network connectivity.12,13 Alzheimer's disease pathogenesis is linked to changes in the DMN's functional connectivity (FC), which can occur years before cognitive symptoms appear.14,15 The research has documented a general decrease in within-network connectivity in the DMN among people who are Aβ-positive.4,16 However, changes in DMN connectivity appear to vary according to the level of Aβ burden and may not be uniform across different regions within the DMN. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.