Further research is needed to investigate the FSH-APOE ε4 interaction in females, particularly given their synergistic activation of the C/EBPβ/δ-secretase pathway in female mice (Xiong et al., 2023) and the association between elevated FSH and AD biomarkers in midlife women (Nerattini et al., 2023). The gene discussed is BRD2; the disease is Alzheimer disease.