These include the NF-κB, MAPK, Wnt, PI3K/AKT/mTOR, and apoptosis pathways (Syed et al., 2016; Wang et al., 2022).This study was aimed to investigate the anti- cancer properties of fisetin in colon cancer Caco-2 cells by studying its effect on cell proliferation and the expression of cell survival pathway genes, including PI3K, AKT, and mTOR, as well as BCL-2 and BAX, which are involved in the apoptosis signaling pathways. Here, AKT1 is linked to malignant colon neoplasm.