The conclusion of the study is that the expression of GPNMB in untreated HNSCC primary tumors and lymph node metastases is higher than that of EGFR, and the correlation of its expression between the two makes GPNMB a promising target for fluorescent imaging in HNSCC (Nichol et al., 2016). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.