Notably, the mediation MR illustrated the causal role of Peptococcus on NSCLC (Total Effect IVW: OR = 0.790, 95% CI [0.657, 0.950], p = 0.012), with a significant mediation by CD45 on HLA DR CD4 in the TBNK panel (−0.034, 95% CI [−0.070, −0.005]; p = 0.037), accounting for 14.4% of the total effect [29]. The gene discussed is PTPRC; the disease is non-small cell lung carcinoma.