Xia et al. have reported that liver X receptor (LXR) beta and PPARD play a critical role in cholestatic liver diseases by regulating cholesterol flux from bile through cholangiocytes in a Niemann–Pick C1-Like L1 (NPC1L1)/ATP-binding Cassette Transporter A1 (ABCA1)–dependent manner [55]. This evidence concerns the gene NPC1L1 and Cholestatic liver disease.