TNFSF10 and non-small cell lung carcinoma: Since TRAIL rapidly induces apoptosis, we determined caspase activation at early time points (1, 2, 3, and 6 hours) in TRAIL-sensitive H460 and TRAIL-resistant A549 and SW1573 NSCLC cells upon exposure to bortezomib and/or rhTRAIL (Figure 1).