The clinical factors, including age, sex, BMI, existence of hypertension and diabetes, medication (diuretics, calcium-blocker, Angiotensin II receptor blocker, angiotensin-converting enzyme inhibitor, and nonsteroidal anti-inflammatory drugs), and base renal function showed no statistical differences between Kuzume's case series [17] and our literature review. This evidence concerns the gene ACE and hypertensive disorder.