Studies have shown that imbalances in copper and zinc ion homeostasis can lead to disturbances in the body’s oxidative-antioxidant system and adversely affect the function of pancreatic islet, thereby triggering or exacerbating the pathological process of diabetes and its complications (29), and its deficiency disrupts insulin homeostasis in vivo, resulting in decreased insulin secretion by beta cells (30). This evidence concerns the gene INS and diabetes mellitus.