The association between ECW/TBW ratio and DPN was significant in all three regression models: Model 1 no variables for adjustment (OR = 2.580, 95% confidence interval: 2.041- 3.263, P<0.001); Model 2 adjusted for sex and age (OR = 3.301, 95% confidence interval:2.403 - 4.535, P<0.001); Model 3 adjusted for sex, age, diabetes duration, smoking, lymphocyte, PLR, MLR, NLR, ALT, AST, total protein, albumin, FPG, FCP, eGFR, BMI and ICW (OR = 3.122, 95% confidence interval: 2.202- 4.424, P<0.001). Here, ALB is linked to diabetes mellitus.