LEP and Insulin resistance: -High association with WAT mass and leptin in women (170, 235, 255–257).-Lower association with BMI, WAT mass and leptin in men (169, 170, 172, 175, 255–258).-Weight loss increases T in older men, and decreases T in older women (229, 230, 259).-Protective against T2D in men (260).-Inversely correlated with insulin resistance in men (236).