To investigate host immune and metabolic responses, we analyzedand integrated public blood flow cytometry, transcriptomics, and untargetedmetabolomics data from simian infection models and human malaria.We found conserved dynamics of blood dendritic cells, effector memoryCD8+ T cells, and PD-1+ effector memory CD8+ T cells in simian infections;increased expression of HMOX1 and coagulation-relatedgenes was conserved in simian infections, while the complement activationgene module was upregulated in rhesus and humans. Here, HMOX1 is linked to malaria.