Patients with LC also have higher serum levels of various other variables, including CRP, insulin-like growth factor (IGF)-1, soluble tumor necrosis factor receptors (sTNF-Rs), TRPM7, uPA, PAI-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2, MCP-1, VEGF, sICAM-1, and MPO.24 Here, TIMP1 is linked to laryngotracheoesophageal cleft.