In the case of NSCLC, research has shown that the serum concentrations of TNF-R1 and TNF-R2 are substantially higher than those in healthy individuals, as evidenced by statistical analysis (Wilcoxon test results: Z = −9.12 [P < 0.0001] for TNF-R1 and Z = −4.11 [P < 0.0001] for TNF-R2).118. The gene discussed is TNFRSF1A; the disease is non-small cell lung carcinoma.