Importantly, tumor cells exhibited increased secretion of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), leading to cytotoxic T lymphocytes (CTLs) activation and dendritic cells (DCs) maturation, accompanied by a reduction in the number of immunosuppressive regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). This evidence concerns the gene TNF and neoplasm.