To compare the expression of the target markers of SB compound in CRC, we checked their expression in The Human Protein Atlas (https://www.proteinatlas.org/), PHB1, PHB2, VDAC1, and FAM20B were generally expressed in CRC, whereas MMP9 showed more marked differences in expression in some CRC cell lines (Figure S8). Here, VDAC1 is linked to colorectal carcinoma.