To compare the expression of the target markers of SB compound in CRC, we checked their expression in The Human Protein Atlas (https://www.proteinatlas.org/), PHB1, PHB2, VDAC1, and FAM20B were generally expressed in CRC, whereas MMP9 showed more marked differences in expression in some CRC cell lines (Figure S8). This evidence concerns the gene PHB2 and colorectal carcinoma.