For instance, under IgG opsonization, the secretion of IFN‐γ secretion is significantly enhanced during E. coli infection [129, 130]; during Salmonella typhi infection, IFN‐γ acts synergistically with TNF‐α and IL‐17A to inhibit bacterial proliferation, enhance macrophage activity, and recruit immune cells [131]; in the presence of IL‐15, MAIT cells exhibit a strengthened IFN‐γ response to Mycobacterium tuberculosis lysates [125]. Here, IFNG is linked to escherichia coli infection.