Single‐cell transcriptome analysis reveals that CXCR6+ CD8+ MAIT cells enhance interactions with the TME through the CXCL16–CXCR6 axis, and their cytotoxicity‐related genes (such as GNLY, PRF1, NKG7) are significantly upregulated, promoting effector T cell infiltration and directly killing tumor cells [210]. This evidence concerns the gene PRF1 and neoplasm.