Specifically, EGFR+ tumors exhibited lower values in original_ngtdm_Coarseness (0.00105 vs. 0.00153, p = 0.0012), original_ngtdm_Strength (5.06 vs. 7.55, p = 0.0015), and PerimeterSurfaceRatio (0.119 vs. 0.140, p = 0.0178), indicating finer texture and more compact tumor structures compared to EGFR− tumors (Supplementary Table S5). This evidence concerns the gene EGFR and neoplasm.