In human squamous cell carcinoma SAS cells, BNCT treatment led to the activation of caspase-9 and caspase-3, as well as the cleavage of poly (ADP-ribose) polymerase-1 (PARP-1) and phosphorylated histone H2AX (γH2AX). The gene discussed is PARP1; the disease is squamous cell carcinoma.