These microRNAs primarily regulate cellular growth, motility, tissue infiltration, and apoptosis by targeting key genes such as CDK6, AKT2, PTEN, and ZEB1/2—for example, the miR-200 family suppresses epithelial–mesenchymal transition (EMT) by targeting ZEB1 and ZEB2, thereby reducing the migratory and invasive capacities of tumor cells. The gene discussed is PTEN; the disease is neoplasm.