- PDE7 isoforms exhibit complex, cancer-type-specific mechanisms and roles as either oncogenic promoters or tumor suppressors- Oncogenic mechanisms involve triggering mitochondrial depolarization, suppressing tumor-suppressive microRNAs (e.g., miR-1/133a), regulating the EMT process, and activating the PI3K/AKT signaling pathway.-Anti-tumorigenic capacities, as its knockdown increases cell viability and migration. The gene discussed is AKT1; the disease is cancer.