Microarray analyses of breast cancer cell lines and patient tissues revealed significant expression of PDE6B, PDE6C, and PDE6D, with minimal to no expression of PDE6A, PDE6G, and PDE6H. Immunohistochemistry confirmed PDE6B protein presence in multiple patient samples and MCF-7 breast cancer cells (126). The gene discussed is PDE6H; the disease is breast carcinoma.