IHC showed HepPar‐1(+), AFP(+), Arg‐1(−), GS(+), GPC3(+), CD34(−), VILLIN(+), CgA(+), Syn(+), Ki‐67 (MIB‐1) (+80%), indicating NEC (large cell type) and HAS with bidirectional differentiation. The gene discussed is AFP; the disease is neuroendocrine carcinoma.