Standard diagnostic biomarkers like B-type Natriuretic Peptide (BNP), NT-proBNP, troponins, and galectin-3, alongside clinical evaluation and echocardiogram imaging, often lack sensitivity and accuracy to fully capture DCM's complexity and prognosis, especially in comorbid patients (69). The gene discussed is NPPB; the disease is familial dilated cardiomyopathy.